Adaptive Oncology

The goal of the Ontario Institute for Cancer Research’s (OICR) Adaptive Oncology Initiative is to develop “adaptive” approaches to cancer management that anticipate how tumours change over the course of time and in response to therapy.

The Initiative, one of OICR’s three key priority research areas, brings together OICR researchers with expertise in genomics, bioinformatics, machine learning, imaging, robotics and histopathology.

Adaptive Oncology Visualization

What do we mean by 'Adaptive Oncology'?

Adaptive Oncology (AO), is a term describing a paradigm in which an understanding of the evolutionary history of a patient’s tumour is used to inform clinical management strategies.

Over the past decade, large cancer genome sequencing efforts have catalogued unexpected diversity amongst cancer genomes. Several hundred novel cancer driver genes have been identified, and a broad spectrum of genomic alterations ranging from single base substitutions to whole genome duplications is now implicated in tumour initiation, progression and therapeutic response. Over the same period, research has discovered extensive spatial and temporal heterogeneity in cancer.

Adaptive Oncology Visualization

We now know that most or all tumours consist of a polyclonal community of genetically distinct cells which evolve over time to adapt to therapy, the immune system, and the microenvironment.

Our Mission and Objectives

Our Mission

OICR’s AO Initiative seeks to develop knowledge and approaches to monitor cancer over its life cycle in order to enable precise and proactive clinical management.

Our research will create the groundwork for new clinical and diagnostic paradigms that use the knowledge of spatial and temporal heterogeneity to select the right therapy at the right time.

In turn, these paradigms will create opportunities for commercialization via knowledge bases of predictive biomarkers, diagnostic testing services, decision software systems, and novel imaging instrumentation.

Our Objectives

  • Build new and deeper understanding of cancer evolution in space and time
  • Develop adaptive approaches to cancer management that anticipate and counter tumour evolution
  • Train the next generation of cancer researchers and engineers to work on adaptive cancer problems
  • Foster efficiency, communication and collaboration within and among Adaptive Oncology, Ontario and the wider cancer research community
  • Establish partnerships to identify and advance adaptive oncology innovations for the benefit of patients and the Ontario economy

Collaborate with Us

Our Services and Expertise are widely available to researchers in Canada and internationally.

Careers

OICR's AO Initiative is always on the lookout for dedicated and talented people to join our culture of innovation and excellence.

Posted Date: September 24, 2019

Visual Web Designer

OICR
Toronto, Ontario
Posted Date: September 10, 2019

Medical Laboratory Technologist

OICR
Toronto, Ontario
Posted Date: September 10, 2019

Program Manager

OICR
Toronto, Ontario
Posted Date: August 29, 2019

Production Team Lead

CPDC
Hamilton, Ontario

What's Happening in AO?

Keep up-to-date with news and event happenings in the AO community.
Learn more about the latest research through our open software, tools, and media files.

Join AO-News Mailing List

Events
Event Dates: November 1, 2019

Courtyard by Marriott Toronto, Toronto, Ontario

Events
Event Dates: October 7, 2019

Canada Science and Technology Museum, Ottawa, Ontario

Our Projects

Our research projects focus on translating our research discoveries and findings to the clinic, and involve collaborations across research institutes, disciplines and geography.

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Leads:
Dr. John Bartlett Dr. Martin Yaffe Dr. Philip Awadalla Dr. Lincoln Stein
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Leads:
Dr. John Bartlett Dr. Philip Awadalla Dr. Lincoln Stein
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Leads:
Dr. Lincoln Stein Dr. Christina Yung
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Leads:
Dr. Aaron Fenster Dr. John Valliant
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Leads:
Dr. Philippe Bedard Dr. Lillian Siu Celeste Yu
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Lead:
Dr. Philip Awadalla

Our Programs

Our Programs have a mandate to support cancer research across OICR and the broad Ontario cancer research community.

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Director:
Dr. Philip Awadalla
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Director:
Dr. John Bartlett
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Director:
Dr. Christina Yung
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Director:
Dr. Trevor Pugh
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Directors:
Dr. Aaron Fenster Dr. Martin Yaffe

Our Resources

Our Resources enable cancer research by developing and providing the fundamental building blocks for cancer research in Ontario and globally.

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Director:
Peter Goodhand
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Directors:
Dr. David Lebrun Dr. Bryan Lo Dr. Harriet Feilotter
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Directors:
Dr. John Bartlett Monique Albert
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Director:
Dr. Trevor Pugh

Our Leadership

OICR's AO Initiative comprises a team of globally recognized lead scientists, clinicians, and engineers, who bring together their expertise for cancer research.

Our Network

OICR's AO Initiative teams are comprised of talented and driven scientists, clinicians, engineers and trainees with one goal in mind: To better the lives of cancer patients through collaborative research.

MORE ABOUT OUR NETWORK

Scientific Advisory Board

Discover the scientific leaders who provide high-level scientific guidance for our AO Initiative.

MORE ABOUT OUR ADVISORS

Our Funders

Funding for OICR’s Adaptive Oncology Initiative is provided by the Government of Ontario.